Jackson was born on April 8, 2002 in New York City. She began her career as a child model appearing in numerous national commercials, including for Band-Aid bandages.
Her first major acting role was in the independent film Liberty Kid (2007), followed an episode of Rescue Me (2008) and the film The Rebound (2009). In 2009, she was cast member of the Nickelodeon pre-school animated series Bubble Guppies playing role of Little Fish. From 2010 to 2011 she guest-starred in the television series Team Umizoomi, Royal Pains, and Boardwalk Empire. She also had small roles in the 2011 films Arthur and The Smurfs.In 2011, she was cast as Zuri Ross in the Disney Channel sitcom Jessie.In 2014, she guest-starred in an episode of Disney XD’s animated series Ultimate Spider-Man. In 2015, a new Disney Channel series Bunk’d, a spin-off of Jessie, was announced where Jackson reprises her role of Zuri Ross.